Database Open Access

Safety and Preliminary Efficacy of Intranasal Insulin for Cognitive Impairment in Parkinson Disease and Multiple System Atrophy

Vera Novak Peter Novak

Published: April 10, 2019. Version: 1


When using this resource, please cite:

Novak, V., Novak, P. (2019). Safety and Preliminary Efficacy of Intranasal Insulin for Cognitive Impairment in Parkinson Disease and Multiple System Atrophy. PhysioNet.

Please include the standard citation for PhysioNet:

Goldberger AL, Amaral LAN, Glass L, Hausdorff JM, Ivanov PCh, Mark RG, Mietus JE, Moody GB, Peng C-K, Stanley HE. PhysioBank, PhysioToolkit, and PhysioNet: Components of a New Research Resource for Complex Physiologic Signals (2003). Circulation. 101(23):e215-e220.

Abstract

A double-blinded placebo-controlled pilot study in parkinson disease and multiple system atrophy.

Parkinson disease (PD) is associated with cognitive impairment. We aimed to determine the effects of intranasal insulin (INI) on cognition and motor performance in PD. This was a proof of concept, randomized, double-blinded, placebo-controlled trial evaluating the effects of 40 international units (IU) of insulin or saline once daily for four weeks on cognitive and functional performance. Of 16 subjects enrolled, eight in the INI group and six in the placebo group completed verbal fluency (FAS), Unified Parkinson Disease Scale (UPDRS), and modified Hoehn and Yahr scale (HY, PD severity) at baseline and post-treatment and were included in the analyses. After treatment, the INI group had a better total FAS score (p=0.02) (41 ± 8.2 vs. 30.8 ± 7.1, mean ±SD, p=0.02) compared to the placebo group. The INI group also had improved HY (p=0.04) and UPDRS-Motor (Part III) (p=0.02) scores when compared to baseline. One INI treated patient with multiple system atrophy (MSA) remained stable and did not show disease progression. The placebo group had no change. INI administration was well tolerated and there were no hypoglycemic episodes or serious study related adverse events or medications interactions.

INI is safe in PD and MSA patients and may provide clinically relevant functional improvement. Larger studies are warranted to determine the INI effect in treatment of cognitive and motor impairment in Parkinson disease. NCT02064166.


Background

Parkinson disease (PD) is associated with a decline in cognitive performance and about 26% of patients diagnosed with PD develop mild cognitive impairment (MCI), more commonly the non-amnestic type [1–3]. The MCI incidence increases with age, disease severity and duration. MCI increases the risk for dementia and disability in PD patients [1, 2, 4] as well as the care-giver’s burden [5]. Insulin plays a key role in glucose metabolism in the brain where it exerts important neuromodulatory, neurotrophic, and neuroprotective effects [6]. Intranasal insulin (INI) administration acutely increased resting-state functional connectivity between hippocampal and DMN regions in patients with type 2 diabetes without affecting serum glucose [7]. INI improved verbal and visuospatial memory in older diabetic and healthy adults, likely via regional vasodilatation in the anterior cerebral circulation [8]. The rationale is that central insulin resistance and consequently impaired insulin signaling in the brain may be the common pathways for cognitive decline with aging, diabetes and Alzheimer’s disease.  In the brain, insulin has vasodilatory and neurotrophic effects, and therefore INI potential benefits are mediated by other mechanisms than by improving peripheral glycemic control.  The effects of INI administration on cognitive performance in patients with PD are yet to be elucidated. We evaluated the cognitive and functional effects of the daily administration of 40 international units (IU) of INI in adults with PD over a four week period as compared to placebo administration. We hypothesized that INI would improve verbal cognition and motor disability in non-demented PD participants after the four weeks of treatment when compared to placebo.


Methods

Participants completed a screening visit, a baseline assessment, two follow-up visits, and an end-of treatment assessment over a four week treatment period. All participants completed detailed medical histories, neurologic physical exams and laboratory investigations (basic metabolic panel and pregnancy test in women of childbearing age). Functional assessments included neuropsychological testing, disease severity scales (to evaluate motor function and disease progression) and a walking test. Functional assessments at baseline and post-treatment were conducted while participants took their usual medications. The last INI/placebo dose administration was on the day of post treatment assessment.

The Montreal Cognitive Assessment (MoCA) test was used to assess symptoms of cognitive impairment [9]. The verbal fluency FAS test was used to assess phonemic fluency and verbal memory [10]. For FAS, participants were asked to name words starting with letters F, A and S over a one-minute interval. The Beck Depression Inventory (BDI) is a 21-item scale that was used to evaluate depressive symptoms [11]. The clinical and motor assessments included the modified Hoehn and Yahr Scale (HY) to evaluate the severity of PD and treatment response [12] and the Unified Parkinson Disease Rating Scale (UPDRS, version modified by the Movement Disorders Society) to clinically assess PD effects on motor, cognitive, and other functions [13]. UPDRS, a widely-used outcome measure in clinical trials, is a sensitive indicator of motor progression and has satisfactory interrater reliability [14, 15]. Motor score was calculated as proposed by Van Rooden et al. [16]. Bradykinesia score was calculated from the UPDRS item 23 + 24 + 25 +26 + 31 bilaterally. Motor asymmetry was estimated using lateralized UPDRS scores (item 20–26) (UPDRS I-III) as suggested by Jankovic et al. [13]. The UPDRS sub-scores summarize: UPDRS-I intellectual, mood and motivation impairment; UPDRS-II eating, activities of daily living, walking and balance; UPDRS-III speech, tremor; Bradykinesia finger tapping, postural stability, and body bradykinesia and dyskinesia.

All participants completed a standard four meter walking test [17] at their preferred walking speed to assess normal walking speed, number of steps and average stride length. The time used to complete a four meter walk was recorded. Average stride length was calculated by dividing the walked distance by the recorded number of steps.


Data Description

PD-Table1.csv  

This file contains the data summary table which includes the pre- and post-intervention study variables and their values for every subject:

  • Group (Insulin-Placebo)
  • Demographics
  • Disease (PD, MSA)
  • Laboratory
  • Vital Signs
  • Walking Test
  • Montreal Cognitive Assessment (MoCA)
  • Becker Depression Inventory (BDI)
  • Verbal Fluency (FAS)

PD-Table2.csv 

This file contains the data summary table which includes the pre- and post-intervention UPDRS values for every subject. The columns updrsN_base and updrsN_tre1 refer to pre- and post-treatment respectively.

Data_Dictionary.csv

This file lists all the variables of the study (variable description and units) and actual values from two participants as examples.

Abbreviations Used

  • MoCA = the Montreal Cognitive Assessment
  • HY = Hoehn and Yahr Scale
  • BDI = Beck Depression Inventory
  • F,A,S = phonemic fluency and verbal memory
  • UPDRS= Unified Parkinson Disease Scale I-III
  • SBP= systolic blood pressure
  • DBP= diastolic blood pressure.

Usage Notes

Pre- and post-intervention variables and values are described in summary tables (PD-Table 1 and Pd-Table2), and a data dictionary, all provided in CSV format.


Acknowledgements

This study was funded in part by The Langer Family Charitable Foundation, Chirag Foundation Investment Trust, Baker’s MSA fund, Mr. Yash R. Puri (awarded to Dr. Peter Novak), and by the Department of Neurology at the University of Massachusetts. Research (manuscript preparation) reported in this publication was in part supported by the National Institute Of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under Award Number R01DK103902 (awarded to Dr. Vera Novak) that is unrelated to this study. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (https://www.niddk.nih.gov/).


Conflicts of Interest

The authors declare no conflicts of interest.


References

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Aarsland-D_Mild-cognitive-impairment-in-Parkinson-disease-a-multicenter-pooled-analysis.pdf 655.2 KB 2019-04-09
Coelho-M_Dementia-and-severity-of-parkinsonism-determines-the-handicap-of-patients-in-late-stage-Parkinsons-disease-the-Barcelona-Lisbon-cohort.pdf 216.9 KB 2019-04-09
Goetz-CG_Movement-Disorder-Society-Task-Force-report-on-the-Hoehn-and-Yahr-staging-scale-status-and-recommendations.pdf 109.9 KB 2019-04-09
Jankovic-J_Variable-expression-of-Parkinsons-disease-a-base-line-analysis-of-the-DATATOP-cohort.pdf 717.1 KB 2019-04-09
Janvin-CC_Subtypes-of-mild-cognitive-impairment-in-Parkinsons-disease-progression-to-dementia.pdf 90.1 KB 2019-04-09
Litvan-I_Diagnostic-criteria-for-mild-cognitive-impairment-in-Parkinsons-disease-Movement-Disorder-Society-Task-Force-guidelines.pdf 777.5 KB 2019-04-09
Litvan-I_MDS-Task-Force-on-Mild-Cognitive-Impairment-in-Parkinsons-Disease-Critical-Review-of-PD-MCI.pdf 156.2 KB 2019-04-09
Maggio-M_Instrumental-and-Non-Instrumental-Evaluation-of-4-Meter-Walking-Speed-in-Older-Individuals.pdf 239.7 KB 2019-04-09
Martinez-MP_Unified-Parkinsons-Disease-Rating-Scale-characteristics-and-structure.pdf 733.0 KB 2019-04-09
Nasreddine-ZS_The-Montreal-Cognitive-Assessment-MoCA-a-brief-screening-tool-for-mild-cognitive-impairment.pdf 84.8 KB 2019-04-09
Novak-V_Enhancement-of-vasoreactivity-and-cognition-by-intranasal-insulin-in-type-2-diabetes.pdf 762.0 KB 2019-04-09
Richards-M_Interrater-reliability-of-the-Unified-Parkinsons-Disease-Rating-Scale-motor-examination.pdf 261.7 KB 2019-04-09
Shemesh-E_Effect-of-intranasal-insulin-on-cognitive-function-a-systematic-review.pdf 543.2 KB 2019-04-09
Van-Rooden-SM_Motor-patterns-in-Parkinsons-disease-a-data-driven-approach.pdf 108.2 KB 2019-04-09
Whisman-MA_Measurement-invariance-of-the-Beck-Depression-Inventory-Second-Edition-BDI-II-across-gender-race-and-ethnicity-in-college-students.pdf 766.8 KB 2019-04-09
Yeudall-LT_Normative-data-for-the-Halstead-Reitan-neuropsychological-tests-stratified-by-age-and-sex.pdf 765.1 KB 2019-04-09
Zhang-H_Intranasal-insulin-enhanced-resting-state-functional-connectivity-of-hippocampal-regions-in-type-2-diabetes.pdf 694.6 KB 2019-04-09